Conference Abstract | Volume 8, Abstract NACNDC/19JASH00070 (Poster) | Published: 11 Dec 2025
Joan Tusubira1, Simon Kasasa1 , Harriet Babikako1, Andrew Tusubira2,3,4
1Department of Epidemiology and Biostatistics, Makerere University School of Public Health, Kampala, Uganda, 2Department of Community Health and Behavioural Sciences, Makerere University School of Public Health, Kampala, Uganda, 3Department of Global Health and Development, Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, London United Kingdom, 4MRC/ UVRI and LSHTM Uganda Research Unit, Entebbe, Wakiso, Uganda
&Corresponding author: Tusubira Joan, Department of Epidemiology and Biostatistics, Makerere University School of Public Health, P.O. Box 7072, Kampala, Uganda. Kampala, Uganda. Email: joantusu@gmail.com ORCID: https://orcid.org/0009-0000-9245-7718
Received: 25 Sep 2025, Accepted: 20 Oct 2025, Published: 11 Dec 2025
Domain: Infectious Disease Epidemiology
Keywords: Tuberculosis preventive therapy, Utilization, People living with HIV, Uganda
©Joan Tusubira et al. Journal of Interventional Epidemiology and Public Health (ISSN: 2664-2824). This is an Open Access article distributed under the terms of the Creative Commons Attribution International 4.0 License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Cite this article: Joan Tusubira et al., Utilization of tuberculosis preventive therapy among adults living with HIV at Kasangati Health Centre IV, Wakiso, Uganda: A mixed-method study. Journal of Interventional Epidemiology and Public Health. 2025;8(ConfProc6):00070. https://doi.org/10.37432/JIEPH-CONFPRO6-00070
Tuberculosis (TB) remains a leading cause of morbidity and mortality among people living with HIV (PLHIV), in resource-limited settings such as Uganda. Effective utilization of Tuberculosis Preventive Therapy (TPT) is essential in reducing TB incidence in this population. We assessed the prevalence of TPT utilization, factors associated and explored the motivators and barriers influencing uptake among adults living with HIV in Uganda.
A mixed-methods study was conducted among adult PLHIV receiving care at Kasangati Health Center IV in Wakiso District. Quantitative data were extracted from facility records of PLHIV aged 18–64 years eligible for TPT between January 2023 and December 2024. Additionally, 12 in-depth interviews were conducted with PLHIV, and seven key informant interviews with healthcare workers were conducted to explore contextual factors affecting TPT utilization. Quantitative analysis involved descriptive statistics and modified Poisson regression; qualitative data were analyzed thematically.
A total of 803 PLHIV were included, with a mean age of 35 years; 71% were women. Overall TPT utilization was 68.2%. Higher utilization was observed among individuals aged 30–41 years (Adj.PR: 1.38; 95%CI: 1.22–1.58), 42–64 years (Adj.PR: 1.44; 95%CI: 1.25–1.67), and overweight individuals (Adj.PR: 1.31; 95%CI: 1.11–1.54). Lower utilization was noted among those residing in rural areas (Adj.PR: 0.74; 95%CI: 0.65–0.84) and married individuals (Adj.PR: 0.84; 95%CI: 0.76–0.93). Key facilitators included TPT awareness, integration into routine HIV care, and shorter regimens such as 3HP. Barriers comprised pill burden, fear of side effects, stock-outs, and long clinic wait times.
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