Conference Abstract | Volume 8, Abstract ELIC2025248 (Oral 067) | Published: 14 Aug 2025
Sheila Mary Ojor Ileli1, Sylvia Chinwendu Olomu1,2, Adewale Elijah Adetunji1,2, Juliet Oemhenze Idialu-Eigbobo1, Imonifome Frank Onyeke1, Chukwuemeka Ogbuinya Ugadu1,2, Victoria Kikelomo Doherty1, Christiana Ngozi Ekuma1,2, Augusta Adesua Orji1, Fidel Chiagozie Ezeome1, Ifeanyi Henry Onyerikam1,2, Matthew Apeleokha1, Grace Gyaga Kyunni1, Chiemeka Jacinta Ogbonnaya1,2, Jeremiah Samual Alli1, Mojeed Olaitan Rafiu3,4, Joseph Okoeguale5,George Obozokhae Akpede1,2,&
1Department of Paediatrics, Irrua Specialist Teaching Hospital, Edo state, Nigeria, 2Department of Paediatrics, Ambrose Alli University, Ekpoma, Edo state, Nigeria, 3Department of Internal Medicine, Irrua Specialist Teaching Hospital, Edo state, Nigeria, 4Department of Internal Medicine, Ambrose Alli University, Ekpoma, Edo state, Nigeria, 5Institute of Viral and Emergent Pathogens Control and Research, Irrua Specialist Teaching Hospital, Edo state, Nigeria
&Corresponding author: George Obozokhae Akpede, Irrua Specialist Teaching Hospital/Ambrose Alli University, Ekpoma, Edo State, Nigeria. Email: georgeakpede@yahoo.co.uk
Received: 20 May 2025, Accepted: 09 Jul 2025, Published: 14 Aug 2025
Domain: Infectious Disease Epidemiology
Keywords: Children, Haemodialysis, impact, outcome, severe Lassa virus disease
©Sheila Mary Ojor Ileli et al Journal of Interventional Epidemiology and Public Health (ISSN: 2664-2824). This is an Open Access article distributed under the terms of the Creative Commons Attribution International 4.0 License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Cite this article: Sheila Mary Ojor Ileli et al., Impact of haemodialysis on the outcome of severe paediatric Lassa virus disease: Question of a half loaf?. Journal of Interventional Epidemiology and Public Health. 2025;8(ConfProc5):00067. https://doi.org/10.37432/JIEPH-CONFPRO5-00067
Previous studies show a strong relationship between the occurrence of severe Acute kidney injury (AKI) and the outcome of paediatric Lassa virus disease (PLVD), and acute intermittent haemodialysis (AIHD) is anticipated to turn this around. However, only limited data are available to guide practice. We present our experience of the impact of AIHD on the outcome of severe PLVD.
It was a retrospective observational study. We reviewed the clinical course and outcome of 25 children with severe (stage 3) AKI in PLVD admitted at Irrua Specialist Teaching Hospital, between January 2018 and March 2025. 13 of the 25 children had AIHD while 12 did not. Illness severity was categorized based on the presence versus absence of haemodynamic instability plus/minus other severity indices and outcome as survived versus died. Groups were compared using Chi square or Fisher’s exact tests, level of significance was set as p <0.05.
Haemodynamic instability plus/minus other indices of illness severity were present in 4/13 (31%) dialyzed vs 7/12 (58%) undialyzed children (OR (95% CI) 0.32 (0.06,1.64), p = 0.166). Case fatality rate was 7/13 (54%) among dialyzed vs 10/12 (83%) undialyzed children (OR = 0.23 (0.04, 1.51), p = 0.250). The average number of dialysis sessions was 3.4 (range 1 – 6), and 3/13 (23%) dialyzed children had intradialytic complications.
Dialysis had no significant impact on the outcome of severe PLVD perhaps due to the presence of severe non-renal organ dysfunctions, especially haemodynamic instability. This is representative of ‘a half loaf is better than none’ scenario and emphasizes the need for continuous renal replacement therapy (CRRT), which is recommended for haemodynamically unstable children. Pending access to CRRT, however, we recommend the need for operational studies involving optimization of AIHD with exchange blood/plasma transfusion and more dialysis sessions among others.
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