Research Open Access | Volume 9 (3): Article 119 | Published: 21 Jul 2026

Prevalence and risk factors of hypertension among patients with hydrocele in Dar es Salaam, Tanzania, 2022

   Menu, Tables and Figures

Navigate this article

Table 1: Social and demographic characteristics of patients with hydrocele in Dar es Salaam, 2022 (N=484)

Table 2: Association of hypertension and its risk factors among patients with hydrocele in Dar es Salaam, 2022 (N=484)

Table 3: Factors associated with hypertension among patients with hydrocele in Dar es Salaam Region, 2022 (N=484)

Figure 1: Data extraction and cleaning processing

Figure 1: Data extraction and cleaning processing

Figure 2: Districts’ pattern of hypertension prevalence among patients with hydrocele in Dar es Salaam, 2022 (N=484)

Figure 2: Districts’ pattern of hypertension prevalence among patients with hydrocele in Dar es Salaam, 2022 (N=484)

Keywords

  • Hypertension
  • Hydrocele
  • Lymphatic Filariasis
  • Integrated approach
  • Management

Sephord Saul Ntibabara1,2,&, Khadija Yahaya Malima3, Evelyne Ngoli1,2, Godbless Henry Mfuru1,2, Farida Ollomi4, Roza Ernest2, Ibrahimu Makongwa5, Dorica Burengelo6, Stephen Mbwambo4, Nsiande Lema2, Clarer Jones4, Omary Ubuguyu7, Faraja Lyamuya4

1Department of Epidemiology and Biostatistics, Muhimbili University of Health and Allied Sciences, P. O. Box 65001, Dar es Salaam, Tanzania, 2Tanzania Field Epidemiology and Laboratory Training Program (TFELTP), Ministry of Health, P.O. Box 743, Dodoma, 3Department of Nursing Management, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam, Tanzania, 4Neglected Tropical Diseases Control Program (NTDCP), Ministry of Health, P.O. Box 743, Dodoma, 5Research and Training Committee, Amana Regional Referral Hospital, P.O. Box 25411, Ilala, Dar es Salaam, 6Research Triangle Institute (RTI International), P.O. Box 369, Dar es Salaam, Tanzania, 7Non-communicable diseases section, Ministry of Health, Ministry of Health, P.O. Box 743, Dodoma.

&Corresponding author: Sephord Saul Ntibabara, P.O.Box 65001, Dar es Salaam, Tanzania. Email: sephordsaul@gmail.com, ORCID: https://orcid.org/0009-0001-4487-512X

Received: 22 Jun 2025, Accepted: 09 Jul 2026, Published: 21 Jul 2026

Domain: Non-Communicable Disease Epidemiology

Keywords: Hypertension, Hydrocele, Lymphatic Filariasis, integrated approach, management

©Sephord Saul Ntibabara et al. Journal of Interventional Epidemiology and Public Health (ISSN: 2664-2824). This is an Open Access article distributed under the terms of the Creative Commons Attribution International 4.0 License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Cite this article: Sephord Saul Ntibabara et al. Prevalence and risk factors of hypertension among patients with hydrocele in Dar es Salaam, Tanzania, 2022. Journal of Interventional Epidemiology and Public Health. 2026; 9(3):119. https://doi.org/10.37432/jieph-d-25-00146

Abstract

Introduction: Hypertension is one of the leading causes of premature death worldwide. The last national survey reveals that in Tanzania, about 26% of all young adults aged 25-64 were estimated to have hypertension in 2013. Patients with Lymphatic Filariasis (LF) who develop hydrocele may be at high risk of developing hypertension due to their physically inactive lifestyle. Magnitude and factors associated with hypertension among hydrocele patients have not been determined. The study was done to determine the prevalence of hypertension and its associated factors among individuals with hydrocele due to LF in the Dar es Salaam region.
Methods: A cross-sectional analysis of secondary data was conducted among patients with lymphatic filariasis–related hydrocele undergoing pre-surgical screening. Hypertension was defined as systolic blood pressure (BP) ≥ 140 mmHg and/or diastolic BP ≥90 mmHg. A chi-square test was performed to determine the significance of differences in hypertension across variables. A modified multivariate Poisson regression analysis was performed to determine the association between variables while adjusting for confounders. P-value ≤0.05 at 95% CI was statistically considered significant.
Results: Among 484 patients with Lymphatic Filariasis hydrocele analysed, the prevalence of hypertension among the patients was 43.4% (n=211, 95%CI 39.2-48.1). Patients aged  45 years had a higher risk [Adjusted Prevalence Ratio (APR) 2.5, 95%CI: 1.35 – 4.64] of developing hypertension. Being diabetic (>7mmol/L) had a 52% (APR=1.52, 95% CI: 1.17-2.00) higher prevalence of hypertension. Obese patients had a 36% higher risk (APR =1.36, 95% CI: 1.05-1.75) of developing hypertension as compared to those with a normal body mass index. Other factors, including education, occupation, marital status, ivermectin/albendazole use, and duration of hydrocele, were not statistically significant after adjustment.
Conclusion: The findings highlight a potential link between hydrocele due to lymphatic filariasis and hypertension, with its elevated risk. Integrating non-communicable disease management, particularly hypertension screening and care, into existing lymphatic filariasis programs could enhance patient outcomes. The LF elimination program is encouraged to consider such integrated approaches in affected regions.

Introduction

Lymphatic filariasis (LF) is among the neglected tropical diseases in Sub Saharan Africa affecting poor communities [1–3]. In Tanzania, it is most prevalent in coastal regions, where a 5.8% prevalence has been reported [4]. Individuals with LF can live with the disease for about 6-8 years, during which most of them develop hydrocele [4]. This wide duration exposes them to a long inactive lifestyle, which exposes them to the risk of hypertension and other non-communicable diseases. The few available studies have revealed lymphatic hypertension due to obstruction of the lymphatic system [5].

Globally, about 1.28 billion individuals aged between 30 and 79 are estimated to have hypertension [6]. The burden of the disease is rapidly increasing in Africa, with the prevalence reaching 27.9% in 2019 [7]. This is attributed to changes in lifestyle with increasing practices of risky behaviours such as high alcohol intake and cigarette smoking. In low-income countries in 2019, alcohol consumption was reported to be higher (45.4%) compared to high-income countries (38.7%) [7].

The only national hypertension survey done in 2012 revealed that 26% of Tanzanians aged between 25 and 64 years of age have hypertension [8,9]. The same survey reported that 32.4% of the Tanzanian population does not engage in vigorous activity [8]. In 2020, in Tanzania, 4 million Tanzanians were reported to have hypertension, of whom 82.4% were not screened, and only 0.1 million individuals were on management strategies [10]. The burden of disease was believed to be high among the rich and also among those who live in urban areas; however, the pattern of disease has currently changed with the increasing burden in rural areas. Studies have revealed a 48.3% prevalence of hypertension in rural areas in Tanzania, showing the shift over a short period [11].

There is an increasing risk of hypertension among individuals with comorbidities such as Human Immuno-Deficiency Virus (HIV) and diabetes [12,13]. In Tanzania, a study reported that about 6.9% of individuals with diabetes mellitus had hypertension comorbidities [14]. Up-to-date studies that explain the association between hypertension and LF are very limited.

We therefore examined the prevalence of hypertension and associated factors among patients with hydrocele residing in Dar es Salaam, Tanzania. The findings may inform integration of hypertension screening and non-communicable disease care into lymphatic filariasis morbidity management services.

Methods

Study design and data collection
This study was a secondary analysis of data obtained from a cross-sectional survey conducted among patients with lymphatic filariasis-related hydrocele in Dar es Salaam, Tanzania. The original survey collected data from patients presenting for hydrocelectomy during a hydrocele surgery campaign. Prior to surgery, eligible patients were screened, provided written informed consent, and completed a pre-tested, structured questionnaire administered by trained healthcare workers. The anonymized dataset from the parent survey was subsequently used for the present analysis.
The dataset included socio-demographic characteristics (age, occupation, residence, education, and marital status), clinical characteristics (duration of living with hydrocele, diabetes status, and history of ivermectin and albendazole use), anthropometric measurements (height and weight), and blood pressure measurements. During the original survey, blood pressure was measured using calibrated digital blood pressure monitors, while height and weight were measured using WHO-certified weighing scales and stadiometers available at the participating health facilities, following the standardized data collection protocol.

For the present study, hypertension was defined as a systolic blood pressure ≥140 mmHg and/or a diastolic blood pressure ≥90 mmHg, in accordance with the Tanzania Standard Treatment Guidelines [15]. Body mass index (BMI) was calculated from the recorded height and weight measurements and categorized according to the WHO adult classification as underweight (<18.5 kg/m²), normal weight (18.5–24.9 kg/m²), overweight (25.0–29.9 kg/m²), and obese (≥30.0 kg/m²) [16]. Occupation was categorized as blue-collar or white-collar using established definitions [17]. Financial hardship was defined based on the parent survey records indicating that participants were unable to afford treatment for hydrocele before the surgery campaign. Hydrocele was analyzed as a single clinical entity irrespective of laterality (unilateral or bilateral), as this information was not disaggregated in the parent dataset.

Study setting
Dar es Salaam region is located in the eastern part of Tanzania along the Indian Ocean and covers an area of 1,393km2. The region is bordered by the Pwani region on all sides, except to the east, where it is borders the Indian Ocean. Dar es Salaam is a densely populated commercial city, with several areas comprising informal settlements marked by substandard living conditions and inadequate access to healthcare services. According to the 2022 census, the Dar es Salaam region has a population of 5 million people [18].

Study population
This secondary analysis used data from a cross-sectional survey conducted among patients with lymphatic filariasis (LF)-related hydrocele who were identified during community-based Transmission Assessment Surveys (TAS) conducted in Dar es Salaam and Pwani regions between 2021 and 2022. The parent survey enrolled patients with hydrocele who had clinical indications for hydrocelectomy and were scheduled to receive surgery during the hydrocele surgery campaign. The present analysis was restricted to participants residing in Dar es Salaam.

Sample size and sampling procedure
The present study utilized an existing dataset generated from the pre-surgical procedure assessment. All participants residing in Dar es Salaam with complete data on the study outcome and key explanatory variables were eligible for inclusion. Of the available records, 484 participants met the inclusion criteria and were included in the analysis. Records from participants residing outside Dar es Salaam or with missing data on variables required for the analysis were excluded.

Data collection procedures in the parent survey
During the assessment, data were collected by trained research assistants who were nurses under the supervision of the principal investigator. The research assistants received standardized training on participant recruitment, informed consent procedures, questionnaire administration, anthropometric measurements, blood pressure measurement, and data quality assurance. Ethical principles, including participant privacy and confidentiality, were emphasized throughout the training.
Eligible participants provided written informed consent before data collection. Information was collected using a structured, pre-tested questionnaire administered before surgery. Blood pressure was measured using calibrated digital blood pressure monitors following the study protocol. Three blood pressure readings were obtained after the participant had rested appropriately, and the average of the two closest readings was recorded. Height and weight were measured using standardized WHO-certified equipment available at the participating health facilities according to the survey protocol.

Definition of key variables
The primary outcome was hypertension. In the present analysis, hypertension was defined as an average systolic blood pressure ≥140 mmHg and/or an average diastolic blood pressure ≥90 mmHg, based on the measurements recorded during the assessment and in accordance with the Tanzania Standard Treatment Guidelines [15].

Data cleaning and data analysis
Data was cleaned using Microsoft Excel version 2013. About 498 patients’ data were obtained from the surgical registry dataset. Of them, 1 (0.2%) had no diastolic measurement and was removed. Of the 497, 13 (2.7%) were removed from the analysis because the participants were from other regions apart from the Dar es Salaam region (Figure 1).

Data analysis
Descriptive analysis was performed by computing frequency and proportions for categorical variables. A measure of central tendency for asymmetrically distributed continuous variables, median with interquartile range (IQR), whereas for normally distributed data, the mean and standard deviation were calculated. The chi-square test was used to compare the distribution of categorical variables according to hypertension status. Modified Poisson regression with robust standard errors was used to estimate prevalence ratios (PRs) for factors associated with hypertension. First, bivariable analyses were performed to examine the crude association between each independent variable and hypertension. Variables considered epidemiologically relevant based on prior evidence, biological plausibility, and data availability in the parent dataset (age, education, occupation, marital status, residence, body mass index, diabetes status, duration of hydrocele, and history of ivermectin/albendazole use) were subsequently included in the multivariable model irrespective of their statistical significance in the bivariable analysis. Because the number of candidate explanatory variables was limited relative to the sample size, all were retained in the final model to ensure adequate adjustment for potential confounding. Crude and adjusted prevalence ratios with their corresponding 95% confidence intervals (CI) were presented. A significance level was set at p-value < 0.05.

Ethical Considerations
From the assessment documents, written informed consent was obtained from all participants prior to data collection, including consent for anonymized publication of study findings. Only de-identified data were accessed and analyzed. Ethical approval was waived by the Ministry of Health’s Ethics Review Committee under the National Institute for Medical Research, as the study utilized routine program data collected during a morbidity management campaign for neglected tropical diseases. The study was conducted in accordance with the principles of the revised Declaration of Helsinki for research involving human subjects. Administrative approval to conduct the study was obtained from the National Neglected Tropical Diseases Control Program (NTDCP). All authors reviewed and approved the final manuscript for publication.

Results

Social demographic characteristics of the study participants
A total of 484 patients with Lymphatic Filariasis Hydrocele were analysed. The mean age (SD) was 50.3(+13.9) years, and 335 patients (70.0%) were  45 years. Of all the patients, 426 (88.0%) had primary education. Of all patients, 445 (91.9%) were of blue-collar jobs. Among all the patients, about three-quarters 359, 74.2%) were married. The median fasting blood sugar level in mmol/L(IQR) was 5.2, ranging between 4.8 and 5.9. Only 39 (8.1%) were found to be diabetic. The median Body Mass Index (IQR) was 24.2 (21.8-27.3). Majority of patients (369; 76.2%) never participated in MDA and never took ivermectin and albendazole medication in their lifetime (Table 1)

Distribution of Hypertension Prevalence among patients with hydrocele in Dar es Salaam
Among 484 patients with hydrocele analysed, the prevalence of hypertension in Dar es Salaam was 43.4% (n=211, 95% CI 39.2-48.1). Among the five districts of Dar es Salaam, Ilala District accounted for 95 patients with hypertension (45.0%; 95% CI: 40.6%–49.5%) (Figure 1). In Dar es Salaam, the prevalence of hypertension increased with age, from 17.3% (9/52) among participants aged ≤35 years to 31.2% (29/93) among those aged 36–44 years, and 51.0% (173/339) among those aged  45 years. Hypertension was more prevalent among participants with no formal education (56.0%, 14/25) compared to those with primary (44.1%, 188/426) and tertiary education (27.3%, 9/33). By occupation, 44.0% (196/445) of blue-collar workers and 38.5% (15/39) of white-collar workers had hypertension. Married participants had a higher prevalence of hypertension (47.6%, 171/359) compared to single participants (32.0%, 40/125). Additionally, hypertension was more common among diabetic individuals (69.2%, 27/39) and those with obesity (57.3%, 43/75), compared to non-diabetic (39.5%, 122/309) and normal BMI participants (37.7%, 97/257) (Table 2).

Factors associated with hypertension among patients with hydrocele in Dar es Salaam in 2022
Patients aged ≥ 45 years had 2.5 times the prevalence of hypertension compared with patients aged ≤35 years (APR=2.50; 95% CI: 1.35–4.64). Patients with obesity had 36% higher prevalence of hypertension (APR 1.36, 95% CI: 1.05-1.75) compared with those who had a normal BMI. Patients with diabetes (>7mmol/L) had 52% higher prevalence of hypertension (APR=1.52, 95% CI: 1.17-2.00), compared with those with normal blood sugar levels. Other factors, including education, occupation, marital status, ivermectin/albendazole use, and duration of hydrocele, were not statistically significant after adjustment (Table 3).

Discussion

A high prevalence of hypertension was observed among patients with hydrocele (43.4%), with prevalence increasing markedly with age. Age ≥45 years, diabetes, and obesity were independently associated with hypertension. These findings suggest a clustering of metabolic risk factors within this population, potentially exacerbated by reduced physical activity and chronic morbidity associated with lymphatic filariasis [19].

The observed prevalence of hypertension among patients with hydrocele was higher than that reported in community-based populations, including pastoralists [9] and individuals without comorbidities [20,21] but lower than estimates from hospital-based studies in Tanzania [22,23]. These differences may reflect variations in study populations and underlying risk profiles. In particular, hospital-based studies are more likely to overestimate prevalence due to selection bias, as they include individuals seeking care who may have a higher burden of comorbid conditions, including non-communicable diseases [24,25].

In contrast, community-based studies may underestimate prevalence due to inclusion of healthier individuals [26]. The intermediate prevalence observed in this study likely reflects the unique clinical profile of patients with hydrocele, who may not be acutely ill but experience chronic morbidity.

On risk factors, our study revealed that ≥ 45 years of age was associated with a higher prevalence of hypertension. This is similar to other studies done, which showed the age of above 30 years to be associated with hypertension [6,11,25]. This underscores the importance of routine hypertension screening in older LF patients, especially those with additional risk factors such as obesity.

During the study, it was found that using ivermectin and albendazole, which are the key preventive chemotherapy, was not associated with hypertension. Although Ivermectin has demonstrated neuroprotective effects in several studies, its potential role in causing hypertension remains only partially investigated [27]. The observation is similar to another study which was done in Tanga region, which showed that hypertension was not among the adverse effects of the drugs [28].

Diabetes was also independently associated with hypertension in this study. This is biologically plausible, as diabetes mellitus contributes to endothelial dysfunction, increased arterial stiffness, and activation of the renin–angiotensin–aldosterone system, all of which elevate blood pressure [29–31]. The coexistence of diabetes and hypertension in this population underscores the growing burden of non-communicable diseases and the need for integrated management approaches.

From our analysis, it was observed that obesity was associated with hypertension; this was also reported in hospital based studies done in Dodoma and Morogoro, Tanzania[6,32]. Excess adiposity contributes to hypertension through multiple mechanisms, including increased sympathetic nervous system activity, insulin resistance, and altered sodium handling [33–35]. However, another study done in northern Tanzania revealed that obesity was not associated with hypertension [26]. However, contrasting findings from other studies [33] may be explained by differences in study populations, measurement approaches, and residual confounding. In the present study, the focus on patients with hydrocele, characterised by reduced mobility and chronic inflammation, may have amplified the observed association between obesity and hypertension.

Moreover, the study did not assess other known risk factors for hypertension, such as alcohol use as revealed to be a significant hypertension risk factor [26] for they were not collected. Surgical morbidity management has been documented to provide permanent relief for patients with hydrocele. However, in Tanzania, misconceptions have been reported as a significant barrier limiting access to care among affected individuals [36].

Strengths and Limitations
This study identified a distinct pattern of hypertension among patients with hydrocele, providing novel evidence from a population that has received limited research attention. By examining the intersection between an infectious disease-related condition and a non-communicable disease, the study contributes to the growing body of evidence supporting integrated approaches to disease prevention and management. Furthermore, the findings provide important baseline data that can inform the design and implementation of integrated healthcare interventions and guide future research in similar settings. However, the cross-sectional design of the study limits the ability to establish temporal or causal relationships between the identified factors and hypertension in patients with hydrocele.

Conclusion

Hypertension is highly prevalent among patients with hydrocele in Dar es Salaam, indicating a substantial co-morbidity burden within this population. Hypertension was more common among older individuals and those with obesity and diabetes, highlighting the importance of metabolic risk factors in this group. These findings suggest that patients receiving hydrocele care represent an important high-risk group requiring integrated hypertension screening and referral, in addition to surgical management. Addressing hypertension within this population may help reduce long-term cardiovascular complications.

Recommendations
The Ministry of Health Tanzania, should integrate routine hypertension screening and management into hydrocele care and lymphatic filariasis programs. Regional and district health management teams should strengthen capacity for early detection and management of non-communicable diseases at primary healthcare level. Targeted health education campaigns should be implemented to address modifiable risk factors, particularly obesity and diabetes, among affected populations. Additionally, the National Neglected Tropical Diseases (NTDs) program manager should incorporate NCD surveillance into existing neglected tropical disease platforms to support continuous monitoring and policy planning.

What is already known about the topic

  • Globally, hypertension is among the major cause of premature death.
  • Being physically inactive is a risk factor associated with hypertension

What this  study adds

  • Individuals with lymphatic filariasis related hydrocele had a high prevalence of hypertension (43.4%), higher than estimates in general population studies.
  • Use of ivermectin and albendazole was not significantly associated with hypertension

Competing interest

The authors of this work declare no competing interests.

Funding

The authors did not receive any specific funding for this work.

Acknowledgements

The authors acknowledge the Tanzania Neglected Tropical Disease Program (NTDCP) for approving the use of program data for this analysis. We also thank USAID, Research Triangle Institute (RTI), for supporting the hydrocele surgery camps and related lymphatic filariasis elimination activities. We are grateful to supervisors from the National Neglected Tropical Diseases Control Program and the Tanzania Field Epidemiology and Laboratory Training Program for their technical support.

Authors’ contributions

Sephord Saul Ntibabara contributed to conceptualization, data curation, formal analysis, investigation, methodology, software, validation, visualization, writing of the original draft, and review and editing of the manuscript. Khadija Yahaya Malima contributed to validation, visualization, and manuscript review and editing. Evelyne B. Ngoli contributed to conceptualization, data curation, formal analysis, methodology, resources, validation, visualization, and writing of the original draft. Godbless Mfuru contributed to conceptualization, data curation, formal analysis, methodology, writing of the original draft, and review and editing. Ibrahimu Makongwa contributed to conceptualization, validation, visualization, writing of the original draft, and review and editing. Farida Ollomyi contributed to conceptualization, data curation, formal analysis, methodology, and manuscript review and editing. Roza Ernest contributed to conceptualization, data curation, formal analysis, methodology, and manuscript review and editing. Dorica Burengelo contributed to project administration, validation, and manuscript review and editing. Jonathan Stephen Mbwambo contributed to conceptualization, formal analysis, investigation, methodology, project administration, supervision, and manuscript review and editing. Nsiande Lema contributed to conceptualization, project administration, supervision, validation, and manuscript review and editing. Clarer Jones contributed to project administration, supervision, visualization, and manuscript review and editing. Omary Ubuguyu contributed to supervision, validation, visualization, and manuscript review and editing. Faraja Lyamuya contributed to conceptualization, project administration, supervision, validation, and manuscript review and editing.

Data availability statement
The datasets generated and analyzed during the current study are available from the corresponding author on reasonable request. All data were anonymized to ensure participant confidentiality.

Tables & Figures

Table 1: Social and demographic characteristics of patients with hydrocele in Dar es Salaam, 2022 (N=484)
VariableFrequency (n)Percentage (n/N, %)
Age (years)  
≤ 355210.8
36–449319.2
≥ 4533570.0
Mean age (SD)50.3 (± 13.9) 
Education  
Never attended school255.2
Primary School42688.0
Tertiary education336.8
District  
Kigamboni326.6
Kinondoni428.7
Temeke17335.7
Ilala21845.0
Ubungo193.9
Occupation  
Blue collar job44591.9
White collar job398.1
Marital status  
Single12525.8
Married35974.2
Diabetes status per blood sugar levels (mmol/L) ©  
Diabetic (>7)398.1
Pre-diabetic (5.6–6.9)13628.1
Non-diabetic (<5.6)30963.8
Median blood sugar (IQR)5.2 (4.8–5.9) 
BMI (Kg/m²)  
Underweight (<18.5)153.1
Normal (18.5–24.9)25753.1
Overweight (25.0–29.9)13728.3
Obesity (≥30)7515.5
Median (IQR)24.2 (21.8–27.3) 
Use of Ivermectin and Albendazole  
Yes11523.8
No36976.2

Note: BMI = Body Mass Index; SD = Standard Deviation. Occupation: “White collar job” = professional, administrative, or managerial roles; “Blue collar job” = manual labor roles involving physical tasks. © Fasting Blood Sugar (mmol/L).

Table 2: Association of hypertension and its risk factors among patients with hydrocele in Dar es Salaam, 2022 (N=484)
VariableWith hypertension n (%)Without hypertension n (%)Chi-Square P-Value
Age (years)  <0.001
≤ 359 (17.3)43 (82.7) 
36–4429 (31.2)64 (68.8) 
≥ 45173 (51.0)166 (49.0) 
Education  0.075
Never attended school14 (56.0)11 (44.0) 
Primary School188 (44.1)238 (55.9) 
Tertiary education9 (27.3)24 (72.7) 
Occupation  0.500
Blue collar job196 (44.0)249 (56.0) 
White collar job15 (38.5)24 (61.5) 
Marital status  0.002
Married171 (47.6)188 (52.4) 
Single40 (32.0)85 (68.0) 
Diabetes status per blood sugar levels (mmol/L)  0.002
Diabetic (>7)27 (69.2)12 (30.8) 
Pre-diabetic (5.6–6.9)62 (45.6)74 (54.4) 
Non-diabetic (<5.6)122 (39.5)187 (60.5) 
BMI (Kg/m²)  0.005
Underweight (<18.5)04 (26.7)11 (73.3) 
Normal (18.5–24.9)97 (37.7)160 (62.3) 
Overweight (25.0–29.9)67 (48.9)70 (51.1) 
Obesity (≥ 30)43 (57.3)32 (42.7) 
Use of Ivermectin and Albendazole  0.537
Yes53 (46.1)62 (53.9) 
No158 (42.8)211 (57.2) 
Table 3: Factors associated with hypertension among patients with hydrocele in Dar es Salaam Region, 2022 (N=484)
VariableHypertension n (%)Crude PR (95% CI)PAdjusted PR (95% CI)P
Age (years)     
≤ 359 (17.3)Ref Ref 
36–4429 (31.2)1.80 (0.92–3.51)0.0841.66 (0.85–3.23)0.135
≥ 45173 (51.0)2.95 (1.61–5.39)<0.0012.50 (1.35–4.64)0.004
Education     
Never attended school14 (56.0)Ref Ref 
Primary School188 (44.1)0.79 (0.55–1.13)0.2000.80 (0.56–1.14)0.214
Tertiary education9 (27.3)0.49 (0.25–0.94)0.0320.60 (0.32–1.13)0.115
Occupation     
Blue collar job196 (44.0)Ref Ref 
White collar job15 (38.5)0.87 (0.58–1.32)0.5180.85 (0.60–1.22)0.387
Marital status     
Married171 (47.6)Ref Ref 
Single40 (32.0)0.67 (0.51–0.89)0.0050.78 (0.60–1.02)0.074
Diabetes status per blood sugar levels (mmol/L)     
Non-diabetic (<5.6)122 (39.5)Ref Ref 
Pre-diabetic (5.6–6.9)62 (45.6)1.15 (0.92–1.45)0.2201.09 (0.87–1.37)0.430
Diabetic (>7)27 (69.2)1.75 (1.36–2.25)<0.0011.52 (1.17–2.00)0.002
BMI (Kg/m²)     
Normal (18.5–24.9)97 (37.7)Ref Ref 
Underweight (<18.5)04 (26.7)0.71 (0.30–1.66)0.4261.18 (0.61–2.28)0.629
Overweight (25.0–29.9)67 (48.9)1.30 (1.03–1.63)0.0291.25 (1.00–1.57)0.053
Obesity (≥30)43 (57.3)1.52 (1.18–1.95)0.0011.36 (1.05–1.75)0.002
Use of Ivermectin and Albendazole     
No158 (42.8)Ref Ref 
Yes53 (46.1)1.08 (0.85–1.36)0.5311.08 (0.87–1.35)0.459
Duration of living with hydrocele (Years) 1.01 (1.00–1.02)0.2991.00 (0.99–1.01)0.408

Note: PR = Prevalence Ratio; CI = Confidence Interval; Ref = Reference category. Bolded adjusted PRs indicate statistically significant associations (P<0.05).

Figure 1: Data extraction and cleaning processing
Figure 1: Data extraction and cleaning processing
Figure 2: Districts’ pattern of hypertension prevalence among patients with hydrocele in Dar es Salaam, 2022 (N=484)
Figure 2: Districts’ pattern of hypertension prevalence among patients with hydrocele in Dar es Salaam, 2022 (N=484)
 

References

  1. World Health Organization. Ending the neglect to attain the Sustainable Development Goals: A road map for neglected tropical diseases 2021–2030 [Internet]. Geneva (Switzerland): WHO; 2021 Jan 28 [cited 2026 Jul 21]. 177 p. Available from: https://www.who.int/publications/i/item/9789240010352
  2. Mwinzi PN, Chimbari M, Sylla K, Odiere MR, Midzi N, Ruberanziza E, Mupoyi S, Mazigo HD, Coulibaly JT, Ekpo UF, Sacko M, Njenga SM, Tchuem-Tchuente LA, Gouvras AN, Rollinson D, Garba A, Juma EA. Priority knowledge gaps for schistosomiasis research and development in the World Health Organization Africa Region [Internet]. Infect Dis Poverty. 2025 Mar 17 [cited 2026 Jul 21];14(1):19. doi:10.1186/s40249-025-01285-w Available from: https://link.springer.com/article/10.1186/s40249-025-01285-w#citeas
  3. Ngunyali DA, Mpomele SS, Kilonzi M, Mutagonda RF, Mikomangwa WP, Mlyuka HJ, Kibanga W, Marealle AI. Knowledge and participation in mass drug administration against lymphatic filariasis and soil-transmitted helminth infections among the community members in Dar es Salaam, Tanzania [Internet]. Transactions of The Royal Society of Tropical Medicine and Hygiene. 2022 Dec 23 [cited 2026 Jul 21];117(5):358–64. doi:10.1093/trstmh/trac119 Available from: https://academic.oup.com/trstmh/article/117/5/358/6958710
  4. Fimbo AM, Minzi OMS, Mmbando BP, Barry A, Nkayamba AF, Mwamwitwa KW, Malishee A, Seth MD, Makunde WH, Gurumurthy P, Lusingu JPA, Kamuhabwa AAR, Aklillu E. Prevalence and Correlates of Lymphatic Filariasis Infection and Its Morbidity Following Mass Ivermectin and Albendazole Administration in Mkinga District, North-Eastern Tanzania [Internet]. JCM. 2020 May 21 [cited 2026 Jul 21];9(5):1550. doi:10.3390/jcm9051550 Available from: https://www.mdpi.com/2077-0383/9/5/1550
  5. Hagiya H, Terasaka T, Kimura K, Satou A, Asano K, Waseda K, Hanayama Y, Takahashi T, Aoe M, Iio K, Watanabe T, Kondo E, Otsuka F. Filarial Chyluria as a Rare Cause of Urinary Retention [Internet]. Intern Med. 2014 [cited 2026 Jul 21];53(17):2001–5. doi:10.2169/internalmedicine.53.2572 Available from: https://www.jstage.jst.go.jp/article/internalmedicine/53/17/53_53.2572/_article
  6. Nyagori HE. Prevalence of Hypertensive Diseases and Associated Risk Factors above 30 Years Adult People Admitted in Morogoro Regional Referral Hospital 2021, Tanzania [Internet]. OALib. 2022 Mar 18 [cited 2026 Jul 21];09(03):e8423. doi:10.4236/oalib.1108423 Available from: https://www.oalib.com/articles/6770346
  7. Schutte AE, Srinivasapura Venkateshmurthy N, Mohan S, Prabhakaran D. Hypertension in Low- and Middle-Income Countries [Internet]. Circulation Research. 2021 Apr 2 [cited 2026 Jul 21];128(7):808–26. doi:10.1161/CIRCRESAHA.120.318729 Available from: https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.120.318729
  8. World Health Organization. Tanzania STEPS Survey-2012: Fact Sheet [Internet]. Geneva (Switzerland): WHO; 2013 [cited 2026 Jul 21]. [2 p.]. Available from: https://extranet.who.int/ncdsmicrodata/index.php/catalog/641/related-materials
  9. Khamis AG, Senkoro M, Mwanri AW, Kreppel K, Mfinanga SG, Bonfoh B, Kwesigabo G. Prevalence and determinants of hypertension among pastoralists in Monduli District, Arusha region in Tanzania: a cross-sectional study [Internet]. Arch Public Health. 2020 Oct 14 [cited 2026 Jul 21];78(1):99. doi:10.1186/s13690-020-00485-0 Available from: https://link.springer.com/article/10.1186/s13690-020-00485-0#citeas
  10. United Republic of Tanzania. United Nations. Department of International Economic and Social Affairs. United Nations Fund for Population Assistance. Population Policy Compendium [Internet]. 1980 Sep [cited 2026 Jul 21]. [1950 – ]. [about 3 screens]. Available from: https://pubmed.ncbi.nlm.nih.gov/12310425/
  11. Muhihi AJ, Anaeli A, Mpembeni RNM, Sunguya BF, Leyna G, Kakoko D, Kessy AT, Mwanyika Sando M, Njelekela M, Urassa DP. Prevalence, Awareness, Treatment, and Control of Hypertension among Young and Middle-Aged Adults: Results from a Community-Based Survey in Rural Tanzania [Internet]. International Journal of Hypertension. 2020 Jan [cited 2026 Jul 21];2020(1):9032476. doi:10.1155/2020/9032476 Available from: https://onlinelibrary.wiley.com/doi/10.1155/2020/9032476
  12. Fahme SA, Bloomfield GS, Peck R. Hypertension in HIV-Infected Adults: Novel Pathophysiologic Mechanisms [Internet]. Hypertension. 2018 May 18 [cited 2026 Jul 21];72(1):44–55. doi:10.1161/HYPERTENSIONAHA.118.10893 Available from: https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.118.10893
  13. Naha S, Gardner MJ, Khangura D, Kurukulasuriya LR, Sowers JR. Hypertension in Diabetes [Internet]. In: Feingold KR, Adler RA, Ahmed SF, Anawalt B, Blackman MR, Chrousos G, Corpas E, de Herder WW, Dhatariya K, Dungan K, Hamilton E, Hofland J, Jan de Beur S, Kalra S, Kaltsas G, Kapoor N, Kim M, Koch C, Kopp P, Korbonits M, Kovacs CS, Kuohung W, Laferrère B, Levy M, McGee EA, McLachlan R, Muzumdar R, Purnell J, Rey R, Sahay R, Shah AS, Sperling MA, Stratakis CA, Trence DL, Wilson DP, editors. Endotext. South Dartmouth (MA): MDText.com, Inc.; 2000- [last update 2021 Aug 7; cited 2026 Jul 21]. [about 15 screens]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK279027/
  14. Mwimo J, Kimondo FC, Mboya IB. Prevalence of hypertension and associated factors among diabetic patients in Kilimanjaro region, northern Tanzania: A hospital-based cross-sectional study [Internet]. Clinical Epidemiology and Global Health. 2023 Aug 8 [cited 2026 Jul 21];23:101387. doi:10.1016/j.cegh.2023.101387 Available from: https://www.ceghonline.com/article/S2213-3984(23)00174-4/fulltext
  15. Tanzania Ministry of Health, Community Development, Gender, Elderly and Children. Standard Treatment Guidelines and National Essential Medicines List, Tanzania Mainland [Internet]. 6th edition. Dodoma (Tanzania): Ministry of Health, Community Development, Gender, Elderly and Children; 2021 [cited 2026 Jul 21]. 598 p. Available from: https://www.moh.go.tz/storage/app/uploads/public/663/c8f/ceb/663c8fceb418d132695047.pdf
  16. World Health Organization. Body mass index (BMI) [Internet]. Geneva (Switzerland): WHO; c2026 [cited 2026 Jul 21]. [about 15 screens]. Available from: https://www.who.int/data/gho/data/themes/topics/topic-details/GHO/body-mass-index
  17. Macdonald D, Vandenabeele C. Glossary of Industrial Relations and Related Terms [Internet]. Geneva (Switzerland): International Labour Organization; 1996 [cited 2026 Jul 21]. 32 p. Available from: https://www.ilo.org/sites/default/files/wcmsp5/groups/public/%40ed_dialogue/%40lab_admin/documents/publication/wcms_111330.pdf
  18. Tanzania National Bureau of Statistics. The 2022 Population and Housing Census: Administrative Units Population Distribution Report: Volume 1A [Internet]. Dar es Salaam (Tanzania): National Bureau of Statistics; 2022 Dec 17 [cited 2026 Jul 21]. 259 p. Available from: https://www.nbs.go.tz/nbs/takwimu/Census2022/Administrative_units_Population_Distribution_Report_Tanzania_volume1a.pdf
  19. Cvejkus RK, Miljkovic I, Barone Gibbs B, Zmuda JM, Wheeler VW, Kuipers AL. Association of physical activity with blood pressure in African ancestry men [Internet]. Preventive Medicine Reports. 2021 Jun 16 [version of record 2021 Jun 21; cited 2026 Jul 21];23:101458. doi:10.1016/j.pmedr.2021.101458 Available from: https://www.sciencedirect.com/science/article/pii/S2211335521001480?via%3Dihub
  20. Sungwa EE, Kibona SE, Dika HI, Laisser RM, Gemuhay HM, Kabalimu TK, Kidenya BR. Prevalence and factors that are associated with elevated blood pressure among primary school children in Mwanza Region [Internet]. Pan Afr Med J. 2020 Nov 30 [cited 2026 Jul 21];37:283. doi:10.11604/pamj.2020.37.283.21119 Available from: https://www.panafrican-med-journal.com/content/article/37/283/full/
  21. Kavishe B, Biraro S, Baisley K, Vanobberghen F, Kapiga S, Munderi P, Smeeth L, Peck R, Mghamba J, Mutungi G, Ikoona E, Levin J, Bou Monclús MA, Katende D, Kisanga E, Hayes R, Grosskurth H. High prevalence of hypertension and of risk factors for non-communicable diseases (NCDs): a population based cross-sectional survey of NCDS and HIV infection in Northwestern Tanzania and Southern Uganda [Internet]. BMC Med. 2015 May 19 [cited 2026 Jul 21];13(1):126. doi:10.1186/s12916-015-0357-9 Available from: https://link.springer.com/article/10.1186/s12916-015-0357-9#citeas
  22. Pallangyo P. Hypertension in Urban Tanzania: A ticking time bomb [Internet]. Archivos de Medicina. 2020 [cited 2026 Jul 21];16(4):5. Available from: https://dialnet.unirioja.es/descarga/articulo/7561044.pdf
  23. Hertz JT, Sakita FM, Manavalan P, Madut DB, Thielman NM, Mmbaga BT, Staton CA, Galson SW. The Burden of Hypertension and Diabetes in an Emergency Department in Northern Tanzania [Internet]. Ethn Dis. 2019 Oct 17 [cited 2026 Jul 21];29(4):559–66. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC6802168/
  24. Galson SW, Staton CA, Karia F, Kilonzo K, Lunyera J, Patel UD, Hertz JT, Stanifer JW. Epidemiology of hypertension in Northern Tanzania: a community-based mixed-methods study [Internet]. BMJ Open. 2017 Nov 9 [cited 2026 Jul 21];7(11):e018829. doi:10.1136/bmjopen-2017-018829 Available from: https://bmjopen.bmj.com/content/7/11/e018829
  25. Mosha NR, Mahande M, Juma A, Mboya I, Peck R, Urassa M, Michael D, Todd J. Prevalence, awareness and factors associated with hypertension in North West Tanzania [Internet]. Global Health Action. 2017 Jan [cited 2026 Jul 21];10(1):1321279. doi:10.1080/16549716.2017.1321279 Available from: https://www.tandfonline.com/doi/full/10.1080/16549716.2017.1321279
  26. Galson SW, Stanifer JW, Hertz JT, Temu G, Thielman N, Gafaar T, Staton CA. The burden of hypertension in the emergency department and linkage to care: A prospective cohort study in Tanzania [Internet]. PLoS ONE. 2019 Jan 25 [cited 2026 Jul 21];14(1):e0211287. doi:10.1371/journal.pone.0211287 Available from: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211287
  27. Seyyedabadi B, Babataheri S, Naseri M, Laher I, Soraya H. Ivermectin and non-parasitic disorders: An update [Internet]. Current Opinion in Pharmacology. 2025 Sep 16 [version of record 2025 Oct 7; cited 2026 Jul 21];85:102574. doi:10.1016/j.coph.2025.102574 Available from: https://www.sciencedirect.com/science/article/abs/pii/S1471489225000700
  28. Fimbo AM, Minzi OM, Mmbando BP, Gurumurthy P, Kamuhabwa AAR, Aklillu E. Safety and Tolerability of Ivermectin and Albendazole Mass Drug Administration in Lymphatic Filariasis Endemic Communities of Tanzania: A Cohort Event Monitoring Study [Internet]. Pharmaceuticals. 2022 May 12 [cited 2026 Jul 21];15(5):594. doi:10.3390/ph15050594 Available from: https://www.mdpi.com/1424-8247/15/5/594
  29. Damayanti VW, Yonata A, Kurniawaty E. Hipertensi pada Diabetes Melitus: Patofisiologi dan Faktor Risiko [Hypertension in Diabetes Mellitus: Pathophysiology and Risk Factors] [Internet]. Medical Profession Journal of Lampung. 2023 Dec 20 [cited 2026 Jul 21];13(7):1253–7. doi:10.53089/medula.v13i7.896 Available from: https://www.journalofmedula.com/index.php/medula/article/view/896
  30. Kushiro T, Kario K, Saito I, Teramukai S, Sato Y, Okuda Y, Shimada K. Increased cardiovascular risk of treated white coat and masked hypertension in patients with diabetes and chronic kidney disease: the HONEST Study [Internet]. Hypertens Res. 2016 Aug 11 [cited 2026 Jul 21];40(1):87–95. doi:10.1038/hr.2016.87 Available from: https://www.nature.com/articles/hr201687#citeas
  31. Ohishi M. Hypertension with diabetes mellitus: physiology and pathology [Internet]. Hypertens Res. 2018 Mar 19 [cited 2026 Jul 21];41(6):389–93. doi:10.1038/s41440-018-0034-4 Available from: https://www.nature.com/articles/s41440-018-0034-4#citeas
  32. Katatwire DD, Meremo A. High prevalence of uncontrolled hypertension among patients with early chronic kidney disease attending tertiary hospitals in Dodoma, Tanzania [Preprint] [Internet]. Research Square. 2022 [posted 2022 Oct 17; cited 2026 Jul 21]. doi:10.21203/rs.3.rs-2146111/v1 Available from: https://www.researchsquare.com/article/rs-2146111/v1
  33. Hall JE, Da Silva AA, Do Carmo JM, Dubinion J, Hamza S, Munusamy S, Smith G, Stec DE. Obesity-induced Hypertension: Role of Sympathetic Nervous System, Leptin, and Melanocortins [Internet]. Journal of Biological Chemistry. 2010 Jun 4 [cited 2026 Jul 21];285(23):17271–6. doi:10.1074/jbc.R110.113175 Available from: https://www.jbc.org/article/S0021-9258(19)35467-5/fulltext
  34. Esler MD, Osborn JW, Schlaich MP. Sympathetic Pathophysiology in Hypertension Origins: The Path to Renal Denervation [Internet]. Hypertension. 2024 Jun [cited 2026 Jul 21];81(6):1194–205. doi:10.1161/HYPERTENSIONAHA.123.21715 Available from: https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.123.21715
  35. Hall JE, Do Carmo JM, Da Silva AA, Wang Z, Hall ME. Obesity-Induced Hypertension: Interaction of Neurohumoral and Renal Mechanisms [Internet]. Circulation Research. 2015 Mar 13 [cited 2026 Jul 21];116(6):991–1006. doi:10.1161/CIRCRESAHA.116.305697 Available from: https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.116.305697
  36. Makwetta H. Misconceptions delay hydrocele treatment along Tanzania’s coast [Internet]. The Citizen. 2025 Aug 22 [cited 2026 Jul 21]. Available from: https://www.thecitizen.co.tz/tanzania/news/national/misconceptions-delay-hydrocele-treatment-along-tanzania-s-coast-5163924
Views: 33