Conference Abstract | Volume 8, Abstract ELIC2025336 (Poster 078) | Published:  04 Aug 2025

Lassa hemorrhagic fever and haematologic dysregulation: Insights from Federal Medical Center, Owo, Ondo State, Nigeria

Ronke Uzuajemeh Ireneh1,&, Johnson Etafo1, Olufunke Bosede Gbenga-Ayeni1, Nelson Akinola Adedosu1

1Infection Control and Research Laboratory, Federal Medical Centre, Owo, Nigeria

&Corresponding author: Ronke Uzuajemeh Ireneh, Federal Medical Centre,  Owo, Nigeria, Email: ronkeireneh@gmail.com

Received: 31 May 2025, Accepted: 09 Jul 2025, Published: 04 Aug 2025

Domain: Infectious Disease Epidemiology

This is part of the Proceedings of the ECOWAS 2nd Lassa fever International Conference in Abidjan, September 8 – 11, 2025

Keywords: Lassa haemorrhagic fever (LHF), cycle threshold (Ct), White blood cell (WBC), Haematocrit (HCT), Platelets (PLT)

©Ronke Uzuajemeh Ireneh et al. Journal of Interventional Epidemiology and Public Health (ISSN: 2664-2824). This is an Open Access article distributed under the terms of the Creative Commons Attribution International 4.0 License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Cite this article: Ronke Uzuajemeh Ireneh et al., Lassa hemorrhagic fever and haematologic dysregulation: Insights from Federal Medical Center, Owo, Ondo State, Nigeria. Journal of Interventional Epidemiology and Public Health. 2025;8(ConfProc5):00222. https://doi.org/10.37432/JIEPH-CONFPRO5-00222

Introduction

Lassa hemorrhagic fever (LHF), a viral zoonotic illness endemic to West Africa, poses significant challenges to clinical diagnosis and management due to its nonspecific presentation and complex pathophysiology. Haematologic abnormalities are hallmark features that may serve as diagnostic and prognostic indicators. 

Methods

A random selection of 200 confirmed cases of LHF between 2021 and 2024 (50 per year) and their haematologic parameters (WBC, HCT  and PLT) analysed using microsoft Excel and Microsoft Power BI in relation to their cycle threshold (Ct) for LHF for different age groups and gender at the Federal Medical Centre, Owo, Ondo State, Nigeria. 

Results

The findings reveal significant leukocytosis, anemia, and thrombocytopenia in severe cases, with strong correlations between haematologic indices and clinical outcomes. The female gender were more predisposed to the infection with 16.5% compared to their male counterparts with 14%.

Conclusion

These results highlight the importance of routine haematological assessments in endemic regions for early detection and effective disease management.

 

 
PDF in Progress

Views: 38

Menu

Navigate this article

Keywords

  • Lassa haemorrhagic fever (LHF)
  • Cycle threshold (Ct)
  • White blood cell (WBC)
  • Haematocrit (HCT)
  • Platelets (PLT)
Views: 38